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LIV

Low-Intensity Vibration, or LIV for short, is a form of vibration with low force. LIV works as a mechanical stimuli on a microscopic level, where deformation occurs on cells and triggers a physiological process in the body. This process is called mechanotransduction. LIV can be generated by a device and be used to stimulate beneficial biological responses in the body.

Recent clinical studies show that LIV can be used to treat brittle-bone disease[1]. Recent smaller studies have shown that LIV shows a potential to treat non-healing wounds, i.e. wounds that per definition does not show significant healing within 30 days[2].

There are studies on the effect of LIV on wound healing in animals and on blood flow in humans. The results have been the following:

• LIV increases blood flow by creating frictional forces on the inner walls of blood vessels, causing them to expand and allow more blood to pass. This is a natural reaction seen during exercise[3].
• LIV reduces inflammation. Macrophage is a type of white blood cell known to be very important in the natural wound healing process. LIV changes its function from inflammatory to anti-inflammatory[4]. Neutrophils is another type of white blood cell that causes inflammation of the wound and is reduced by LIV[5][6].
• LIV increases regeneration by increasing tissue growth and growth factors that help produce new blood vessels, skin cells, stem cells and the support structure of surrounding cells[7][8].
• LIV reduces bacterial load by increasing macrophages accumulation[9].
• LIV decreases blood glucose levels in diabetics by around 19%[10], contributing to countering the harmful effects of high blood sugar on the immune system and reduces the risk of infection[11].

Currently we are preparing for a clinical study to show the effectiveness of LIV in treatment of patients with grade 2 diabetic foot ulcers. If you are interested to know more to test the device yourself, please reach out to us.

[1] “vibration treatment modulates macrophage … – eCM Journal.” https://www.ecmjournal.org/papers/vol038/pdf/v038a16.pdf. Öppnades 17 aug.. 2020.
[2] “Chronic Wounds, Overview and Treatment | WoundSource.” https://www.woundsource.com/patientcondition/chronic-wounds. Öppnades 17 aug. 2020.
[3] “Effect of Vibration on Skin Blood Flow in an in Vivo … – PubMed.” https://pubmed.ncbi.nlm.nih.gov/20103887/. Öppnades 17 aug.. 2020.
[4] “vibration treatment modulates macrophage … – eCM Journal.” https://www.ecmjournal.org/papers/vol038/pdf/v038a16.pdf. Öppnades 17 aug.. 2020.
[5] “The Cellular Biology of Wound Healing.” https://www.neuro.ki.se/neuro/KK2/Jimmy_GoogleCACHE1.html. Öppnades 17 aug.. 2020.
[6] “vibration treatment modulates macrophage … – eCM Journal.” https://www.ecmjournal.org/papers/vol038/pdf/v038a16.pdf. Öppnades 17 aug.. 2020.
[7] “Low-Intensity Vibration Improves Angiogenesis … – NCBI – NIH.” 11 mars. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950202/. Öppnades 17 aug.. 2020.
[8] “vibration treatment modulates macrophage … – eCM Journal.” https://www.ecmjournal.org/papers/vol038/pdf/v038a16.pdf. Öppnades 17 aug.. 2020.
[9] “The Cellular Biology of Wound Healing.” https://www.neuro.ki.se/neuro/KK2/Jimmy_GoogleCACHE1.html. Öppnades 17 aug.. 2020.
[10] “Low-Intensity Vibration Improves Angiogenesis … – NCBI – NIH.” 11 mars. 2014, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3950202/. Öppnades 17 aug.. 2020.
[11] “High blood sugar of diabetes can cause immune system ….” 6 aug.. 2015, https://www.sciencedaily.com/releases/2015/08/150806151354.htm. Öppnades 17 aug.. 2020.