Low-Intensity Vibration, or LIV for short, is a form of vibration with low force. LIV works as a mechanical stimuli on a microscopic level, where deformation occurs on cells and triggers a physiological process in the body. This process is called mechanotransduction. LIV can be generated by a device and be used to stimulate beneficial biological responses in the body. 

Recent clinical studies show that LIV can be used to treat brittle-bone disease. Recent smaller studies have shown that LIV shows a potential to treat non-healing wounds, i.e. wounds that per definition does not show significant healing within 30 days. 

There are studies on the effect of LIV on wound healing in animals and on blood flow in humans. The results have been the following: 

  • LIV increases blood flow by creating frictional forces on the inner walls of blood vessels, causing them to expand and allow more blood to pass. This is a natural reaction seen during exercise. 
  • LIV reduces inflammation. Macrophage is a type of white blood cell known to be very important in the natural wound healing process. LIV changes its function from inflammatory to anti-inflammatory. Neutrophils is another type of white blood cell that causes inflammation of the wound and is reduced by LIV.
  • LIV increases regeneration by increasing tissue growth and growth factors that help produce new blood vessels, skin cells, stem cells and the support structure of surrounding cells.
  • LIV reduces bacterial load by increasing macrophages.

LIV decreases blood glucose levels in diabetics by around 19%, contributing to countering the harmful effects of high blood sugar on the immune system and reduces the risk of infection.

Currently we are preparing for a clinical study to show the effectiveness of LIV in treatment of patients with grade 2 diabetic foot ulcers. If you are interested to know more to test the device yourself, please reach out to us.

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